PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
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PROTAC Linkers Related Products (4095)
Related Products (4095)
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PROTAC Linkers Isoform Comparison
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NH2-PEG5-C2-NH-Boc
0 ImagesCat. No.: HY-W022240CAS No.: 189209-27-6Synonyms: PROTAC Linker 17
![tert-Butyl 2-hydroxy-7-azaspiro[3.5]nonane-7-carboxylate](https://file.medchemexpress.com/product_pic/hy-w052528.gif "Click to View tert-Butyl 2-hydroxy-7-azaspiro[3.5]nonane-7-carboxylate Product Detail")
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2-((tert-Butyldimethylsilyl)oxy)ethanol
0 ImagesCat. No.: HY-91023CAS No.: 102229-10-7
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m-PEG4-NHS ester
0 ImagesCat. No.: HY-124323CAS No.: 622405-78-1
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BCN-PEG4-NHS ester
0 ImagesCat. No.: HY-133439CAS No.: 1702356-19-1
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Mal-PEG1-NHS ester
0 ImagesMal-PEG1-NHS ester is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Mal-PEG1-NHS ester is PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
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1-N-Boc-3-hydroxyazetidine
0 Images1-N-Boc-3-hydroxyazetidine is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 1-N-Boc-3-hydroxyazetidine is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs
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tert-butyl (5-bromopentyl)carbamate
0 ImagesCat. No.: HY-77483CAS No.: 83948-54-3
![2-Boc-2-Azaspiro[3.3]heptane-OH](https://file.medchemexpress.com/product_pic/hy-20236.gif "Click to View 2-Boc-2-Azaspiro[3.3]heptane-OH Product Detail")
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Azido-PEG1-NHS ester
0 ImagesAzido-PEG1-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG1-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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NH2-PEG6-Boc
0 ImagesNH2-PEG6-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. NH2-PEG6-Boc is also a non-cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
